Next, with the disc still in transport position, use the rockshaft height adjustment to level the wings. Start by raising and lowering the disc and folding it for four cycles to purge any air in the lines and make sure the phasing cylinders are in sync. This step is especially important if you are using a disc with differently sized tires on the wings and the center section, which can cause uneven cutting. If you are using a folding disc like AMCO’s F15 Double Offset Tandem Disc Harrow, the next step is to level the wings so the blades cut at an even depth across the unit. Once you’ve finished prepping the disc, put it in a travel position and move it to level ground where you can continue with the next steps. Connected all hydraulic hoses and lighting connectors.Installed the drawbar, pin, and lock pin.To make sure the disc is correctly attached to the tractor, check that you have: Never put yourself between pinching points. Use extreme caution when performing the following steps. To help you reap the benefits of a properly set disc, AMCO has put together this guide to setting our disc harrows.īefore making any adjustments, make sure the tractor is in park and the key is removed. By taking a little extra time to check your disc, you can ensure you make fewer trips to the field, reduce the risk of erosion, and lay the level groundwork for a successful crop. 'A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia'.Whether you’re managing residue, working a seedbed, or prepping for the next crop rotation, a properly set disc is crucial.'A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)'.'The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia'.
'ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling'.'The European Hematology Association Roadmap for European Hematology Research: a consensus document'.'Long noncoding RNA signatures define oncogenic subtypes in T-cell acute lymphoblastic leukemia'.'A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network'.'Deletion 6q drives T-cell leukemia progression by ribosome modulation.'ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms'.'Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition' Science Translational Medicine 2019 11:494.'A cell atlas of human thymic development defines T cell repertoire formation'. Science.'Integrated single cell RNAseq identifies human postnatal thymus seeding progenitors and regulatory dynamics of differentiating immature thymocytes'.'Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development'. Nature Immunology.By studying the changes in gene expression that occur upon such perturbations, these insights provide novel opportunities for targeted therapy. In addition, since many of the key transcriptional regulators of normal T lymphocyte development are often aberrantly expressed in T-acute lymphoblastic leukemia, another part of our work aims to reveal how gain- or loss-of-function expression of these factors alters normal T cell development and contributes to oncogenic transformation. By obtaining novel insights into the molecular network that induces the step-wise conversing of hematopoietic stem cells into T lymphocytes, we aim to improve the development of these immune cells following stem cell transplantation. In clinical settings where hematopoietic stem cells are transplanted to rebuild the immune system, for instance following chemotherapy with the aim to eradicate cancer cells, the recovery of T lymphocytes is slow and often limited, leading to a prolonged phase of immune deficiency in which patients are highly susceptible to infections. T lymphocytes are vital cells of the immune system and comprise a particular type of blood cells that is generated from the blood forming hematopoietic stem cells. The overall goal of our work is to understand the transcriptional network that induces and controls T cell development in human.
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